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AC-099 hydrochloride

CAS No. 849335-07-5

AC-099 hydrochloride( —— )

Catalog No. M37320 CAS No. 849335-07-5

AC-099 hydrochloride is a selective full agonist of the neuropeptide FF2 receptor NPFF2R (EC50=1189 nM) and partial agonist function of the neuropeptide FF1 receptor NPFF1R (EC50=2370 nM) that reverses opioid-induced nociceptive sensitization, and may be used to study neurological.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AC-099 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    AC-099 hydrochloride is a selective full agonist of the neuropeptide FF2 receptor NPFF2R (EC50=1189 nM) and partial agonist function of the neuropeptide FF1 receptor NPFF1R (EC50=2370 nM) that reverses opioid-induced nociceptive sensitization, and may be used to study neurological.
  • Description
    AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague-Dawley rats (175-300g; spinal nerve ligation (SNL) model).Dosage:30 mg/kg Administration:Intraperitoneal injection; single.Result:Completely attenuated SNL-induced hypersensitivity.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Neuropeptide Y Receptor
  • Recptor
    Neuropeptide Y Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    849335-07-5
  • Formula Weight
    301.1
  • Molecular Formula
    C9H9Cl2F3N4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.FC(F)(F)C1=CC(C=NNC(=N)N)=CC=C1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. ?
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